Steely;
I don't have a .22-250, I use the Swift instead. But I did some research for you.
Nosler #5, using their 50 gr bullet of course, lists H 380 as the most accurate powder. They don't list H 4350. IMR 3031 is listed, but is well off the mark in velocity compared to H 380. Varget is listed & shows average velocity, 36gr going 3794.
Hornady#6, uses the 50 gr V-Max of course, but doesn't list accuracy. They show 3800 fps as max velocity with many powders capable of making that speed. Varget is one, no H 4350. Win 740 & 748, Vihta N140, IMR 4064 & 4320, and RL-15 will all do it.
Speer #13 shows in order of descending speed: AA2460, Varget, RL-15, Viht N135, and H 380. Those go from 3804 on the top to 3693 on the slow end, with H 380 producing the least velocity at max load.
900F